Friends and patients often ask us how technology is changing knee care. Sometimes it’s about knee replacements – are the implants getting better? Is pain-relief science improving? Sometimes it’s about the wider picture – what are the big new developments on the horizon? Will we ever see a cure for arthritis?
They’re great questions. And the good news is that, yes, the outlook for orthopaedic medicine is very exciting at the moment. The technologies available to us are advancing all the time, and so is the effectiveness of our treatments.
Twenty years ago, for example, orthopaedic clinics were filled with patients suffering from rheumatoid disease. Now, thanks to the latest Anti-TNF drugs – medicines that lower inflammation and prevent immune system damage – those numbers have plummeted.
So what are the most promising developments heading our way in the next few years? Here are four emerging technologies that, we think, are worth keeping an eye on.
Cartilage regeneration
Hyaline cartilage, as you may know, is the substance on bone endings that helps joints move without pain and friction. When injury or long-term damage wears away this material, the body can’t simply grow it back again because hyaline cartilage lacks its own blood supply. So the smooth covering becomes permanently depleted (osteoarthritis).
Regenerating hyaline cartilage is extremely difficult, but several research teams around the world are now working on ways to make it happen. One of the most promising is at Stanford University. Scientists there have developed an injectable molecule that blocks “15-PGDH”, an ageing enzyme involved in preventing tissue repair. Early trials have been very encouraging. “The [molecule] causes a dramatic regeneration of cartilage beyond that reported in response to any other drug or intervention,” says one of the researchers.
Read more: Have scientists just found a way to regrow knee cartilage?
Smart knee implants
The artificial implants we use in knee replacements today are lighter, stronger and, crucially, more anatomical than ever before. They feel more natural in the joint and more comfortable to use, and those things are making a discernible difference to patients’ rehab and recovery after surgery.
Smart knees are a newer evolution of the modern implant. Just like smartphones, they have built-in sensors to pick up health-related data in the user. The latest versions include micro-sensors inside the stem extension of the shin bone to record metrics like step count, cadence, range of motion and stride length. This data feeds back to a phone app, where it can be reviewed by both the patient and their surgeon. As they improve, we expect these types of devices to include other metrics like joint load, temperature (to catch infections) and the stability of implant components.
Read on: Are “smart knees” the future of knee replacements?
Weight loss drugs
Not so much an on-the-horizon development as one that’s already with us… Medicines like Wegovy and Mounjaro have upended the way patients approach weight loss. The reason this is significant for knees is because weight plays a critical role in joint pain and osteoarthritis.
Excess weight puts huge pressure on a knee that is already damaged and painful. In the past, that sometimes meant referring patients for bariatric surgery before they could undergo the knee operation they needed. Now, people are shedding the pounds without that extra need for invasive surgery. There are caveats to bear in mind with weight loss drugs, but on the face of it this is good news for arthritis sufferers.
Read more: Can weight loss drugs like Wegovy reduce arthritis knee pain?
Pain relief treatments
A “life-changing, once-a-month jab” that offers hope to long-term osteoarthritis sufferers? That was the headline question that greeted news of “LEVI-04”, a first-of-its-kind medicine that targets the nerves involved in arthritis-related pain. Where many other pain-relieving drugs have focused on blocking pain signals completely, LEVI-04 uses an inhibitor chemical to “scavenge” the excess neurotrophins (proteins involved in nerve cell growth) that are present in chronically painful joints.
After an initial trial involving some 500 people with knee arthritis, patients who were given the injections experienced a 50% drop in pain levels after four months. “I can’t quite believe how good the results are,” the lead researcher from Leeds University said at the time.
Read more: A “game-changing” treatment for knee arthritis pain?
Are you worried about an issue with your knees, or in need of advice and further investigation? We’re here to help you get the support you need. You can book an appointment with Mr Bailey on our website, or by calling us direct on 01962 826107.

